GPCR Evolution Database

Precision evolutionary insights for human G-protein-coupled receptors

Rigorously curated, residue-level evolutionary information for every human GPCR, built from high-quality multiple-sequence alignments and phylogenetic trees.

Accelerating GPCR Research Through Evolution

G-protein-coupled receptors (GPCRs) represent the largest protein family in the human genome and the most lucrative class of drug targets. Our database fills a critical gap by providing evolutionary trajectories that clarify ligand and G protein specificity, accelerate deorphanization, and identify pathogenic variants.

GPCRs are the largest protein family and most lucrative drug targets. Our database provides evolutionary trajectories to clarify specificity and identify pathogenic variants.